A – yes. The authors found that c-Kit is highly expressed and phosphorylated in uveal melanoma cell lines, that autocrine stem-cell-factor/c-Kit signaling supports their survival, and that the c-Kit inhibitor STI-571 (imatinib) induced cell death, indicating c-Kit-dependent growth and its potential as a therapeutic target [All-Ericsson et al., 2004, PMID 15223779].