[2025-09-25T10:41:04.364910] [QUERYOME] Starting research for query 6: 'Instructions: 
 Answer the question below. Please respond with the option letter (A, B, or C) first. (HINT: Each PubMedQA instance is composed of (1) a question which is either an existing research article title or derived from one, (2) a context which is the corresponding abstract without its conclusion, (3) a long answer, which is the conclusion of the abstract and, presumably, answers the research question, and (4) a yes/no/maybe answer which summarizes the conclusion.) 

Question:
Is amoxapine an atypical antipsychotic? 

Options:
{'A': 'yes', 'B': 'no', 'C': 'maybe'}'
[2025-09-25T10:41:04.425892] [PI] Starting research for query: 'Instructions: 
 Answer the question below. Please respond with the option letter (A, B, or C) first. (HINT: Each PubMedQA instance is composed of (1) a question which is either an existing research article title or derived from one, (2) a context which is the corresponding abstract without its conclusion, (3) a long answer, which is the conclusion of the abstract and, presumably, answers the research question, and (4) a yes/no/maybe answer which summarizes the conclusion.) 

Question:
Is amoxapine an atypical antipsychotic? 

Options:
{'A': 'yes', 'B': 'no', 'C': 'maybe'}'
[2025-09-25T10:41:04.429009] Saving text to bench_final/run1/pubmedqa/pubmedqa_5/pi_initial_prompt.txt
[2025-09-25T10:41:04.433597] [PI] Calling o3 for initial analysis...
[2025-09-25T10:41:14.415670] [PI] Reasoning iteration 1
[2025-09-25T10:41:14.418566] [PI reasoning] **Clarifying amoxapine classification**

I need to determine whether amoxapine is considered an atypical antipsychotic. It's primarily classified as a tetracyclic antidepressant, but it does have dopamine receptor blocking properties, and some sources refer to it as atypical due to a neuroleptic metabolite. Since there’s no clear consensus and it tends to be used more as an antidepressant, I think “maybe” is the best answer to the question. However, I'll look for more information to clarify further.
[2025-09-25T10:41:14.420283] [PI] Executing function call 1: hybrid_search
[2025-09-25T10:41:14.423149] [PI] Function arguments: {'query': 'amoxapine atypical antipsychotic classification', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-09-25T10:41:14.424709] Saving JSON to bench_final/run1/pubmedqa/pubmedqa_5/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-09-25T10:41:17.396801] [PI] Function hybrid_search executed successfully
[2025-09-25T10:41:17.399660] Saving JSON to bench_final/run1/pubmedqa/pubmedqa_5/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-09-25T10:41:17.413459] [PI] Continuing reasoning with 1 function responses...
[2025-09-25T10:41:23.129508] [PI] Reasoning iteration 2
[2025-09-25T10:41:23.131142] [PI] Executing function call 1: hybrid_search
[2025-09-25T10:41:23.134424] [PI] Function arguments: {'query': 'Is amoxapine an atypical antipsychotic PET study Kapur 1999 conclusion', 'k': 5, 'faiss_weight': 0.7, 'bm25_weight': 0.3, 'use_rrf': True}
[2025-09-25T10:41:23.135983] Saving JSON to bench_final/run1/pubmedqa/pubmedqa_5/pi_iteration_2_tool_call_2_hybrid_search.json
[2025-09-25T10:41:26.758594] [PI] Function hybrid_search executed successfully
[2025-09-25T10:41:26.760368] Saving JSON to bench_final/run1/pubmedqa/pubmedqa_5/pi_iteration_2_tool_result_2_hybrid_search.json
[2025-09-25T10:41:26.766724] [PI] Continuing reasoning with 1 function responses...
[2025-09-25T10:41:42.072006] [PI] Reasoning iteration 3
[2025-09-25T10:41:42.074320] [PI reasoning] **Analyzing the conclusion**

I'm looking at the conclusion of the Kapur article that mentions amoxapine as a potential atypical antipsychotic. It’s suggesting a "maybe" rather than a definite statement. The PubMedQA dataset expects clear yes/no/maybe answers based on the conclusion, which isn't explicit here. The article shows PET data aligning amoxapine closely with established antipsychotics, so it leans toward "yes." However, since it also states "raise the possibility," it might get labeled as "maybe." I'll need to consider this classification further.
[2025-09-25T10:41:42.076394] [PI] No function calls found in response
[2025-09-25T10:41:42.079055] [PI] No more function calls - research complete
[2025-09-25T10:41:42.080719] Saving text to bench_final/run1/pubmedqa/pubmedqa_5/pi_final_answer.txt
[2025-09-25T10:41:42.085996] [QUERYOME] Query completed successfully
