[2025-09-25T12:00:52.255928] [QUERYOME] Starting research for query 221: 'Instructions: 
 Answer the question below. Please respond with the option letter (A, B, or C) first. (HINT: Each PubMedQA instance is composed of (1) a question which is either an existing research article title or derived from one, (2) a context which is the corresponding abstract without its conclusion, (3) a long answer, which is the conclusion of the abstract and, presumably, answers the research question, and (4) a yes/no/maybe answer which summarizes the conclusion.) 

Question:
Is halofantrine ototoxic? 

Options:
{'A': 'yes', 'B': 'no', 'C': 'maybe'}'
[2025-09-25T12:00:52.348191] [PI] Starting research for query: 'Instructions: 
 Answer the question below. Please respond with the option letter (A, B, or C) first. (HINT: Each PubMedQA instance is composed of (1) a question which is either an existing research article title or derived from one, (2) a context which is the corresponding abstract without its conclusion, (3) a long answer, which is the conclusion of the abstract and, presumably, answers the research question, and (4) a yes/no/maybe answer which summarizes the conclusion.) 

Question:
Is halofantrine ototoxic? 

Options:
{'A': 'yes', 'B': 'no', 'C': 'maybe'}'
[2025-09-25T12:00:52.349650] Saving text to bench_final/run1/pubmedqa/pubmedqa_220/pi_initial_prompt.txt
[2025-09-25T12:00:52.368158] [PI] Calling o3 for initial analysis...
[2025-09-25T12:00:57.677942] [PI] Reasoning iteration 1
[2025-09-25T12:00:57.679555] [PI reasoning] **Evaluating halofantrine's effects**

I’m trying to determine if halofantrine is ototoxic. It's known as an antimalarial medication associated with cardiac toxicity, but what about its effects on hearing? I remember some studies mention that halofantrine and mefloquine have been linked to auditory and vestibular toxicity. There are also case reports around this. So, I need to decide whether the answer is yes, no, or maybe. I'll look into it further.
[2025-09-25T12:00:57.683071] [PI] Executing function call 1: hybrid_search
[2025-09-25T12:00:57.684678] [PI] Function arguments: {'query': 'halofantrine ototoxicity auditory toxicity', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-09-25T12:00:57.687440] Saving JSON to bench_final/run1/pubmedqa/pubmedqa_220/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-09-25T12:01:01.353258] [PI] Function hybrid_search executed successfully
[2025-09-25T12:01:01.355549] Saving JSON to bench_final/run1/pubmedqa/pubmedqa_220/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-09-25T12:01:01.373809] [PI] Continuing reasoning with 1 function responses...
[2025-09-25T12:01:09.642436] [PI] Reasoning iteration 2
[2025-09-25T12:01:09.643949] [PI] No function calls found in response
[2025-09-25T12:01:09.645562] [PI] No more function calls - research complete
[2025-09-25T12:01:09.647717] Saving text to bench_final/run1/pubmedqa/pubmedqa_220/pi_final_answer.txt
[2025-09-25T12:01:09.655831] [QUERYOME] Query completed successfully
