[2025-10-01T00:37:19.042255] [QUERYOME] Starting research for query 983: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Myosin head detachment from actin is triggered by:- 

Options:
{'A': 'Change in troponin c configuration', 'B': 'Entry of Ca into sarcoplasmic reticulum', 'C': 'Binding of ATP to head', 'D': 'Hydrolysis of ATP to ADP and Pi'}'
[2025-10-01T00:37:19.102399] [PI] Starting research for query: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Myosin head detachment from actin is triggered by:- 

Options:
{'A': 'Change in troponin c configuration', 'B': 'Entry of Ca into sarcoplasmic reticulum', 'C': 'Binding of ATP to head', 'D': 'Hydrolysis of ATP to ADP and Pi'}'
[2025-10-01T00:37:19.104419] Saving text to bench_final/run1/medmcqa/medmcqa_982/pi_initial_prompt.txt
[2025-10-01T00:37:19.118614] [PI] Calling o3 for initial analysis...
[2025-10-01T00:37:23.765397] [PI] Reasoning iteration 1
[2025-10-01T00:37:23.768833] [PI] Executing function call 1: bm25_mesh_terms_search
[2025-10-01T00:37:23.770452] [PI] Function arguments: {'query': 'myosin detachment from actin occurs when ATP binds to myosin head', 'k': 5}
[2025-10-01T00:37:23.772087] Saving JSON to bench_final/run1/medmcqa/medmcqa_982/pi_iteration_1_tool_call_2_bm25_mesh_terms_search.json
[2025-10-01T00:37:24.526890] [PI] Function bm25_mesh_terms_search executed successfully
[2025-10-01T00:37:24.528631] Saving JSON to bench_final/run1/medmcqa/medmcqa_982/pi_iteration_1_tool_result_2_bm25_mesh_terms_search.json
[2025-10-01T00:37:24.534792] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T00:37:28.318681] [PI] Reasoning iteration 2
[2025-10-01T00:37:28.320162] [PI] Executing function call 1: hybrid_search
[2025-10-01T00:37:28.321738] [PI] Function arguments: {'query': 'ATP binding causes myosin head to detach from actin cross bridge cycle', 'k': 10, 'faiss_weight': 0.7, 'bm25_weight': 0.3, 'use_rrf': True}
[2025-10-01T00:37:28.323912] Saving JSON to bench_final/run1/medmcqa/medmcqa_982/pi_iteration_2_tool_call_2_hybrid_search.json
[2025-10-01T00:38:32.463599] [PI] Function hybrid_search executed successfully
[2025-10-01T00:38:32.465149] Saving JSON to bench_final/run1/medmcqa/medmcqa_982/pi_iteration_2_tool_result_2_hybrid_search.json
[2025-10-01T00:38:32.503742] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T00:38:39.171923] [PI] Reasoning iteration 3
[2025-10-01T00:38:39.173807] [PI] No function calls found in response
[2025-10-01T00:38:39.178067] [PI] No more function calls - research complete
[2025-10-01T00:38:39.180833] Saving text to bench_final/run1/medmcqa/medmcqa_982/pi_final_answer.txt
[2025-10-01T00:38:39.189594] [QUERYOME] Query completed successfully
