[2025-09-29T14:31:44.492563] [QUERYOME] Starting research for query 95: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
All are drugs which lower IOP except 

Options:
{'A': 'Clonidine', 'B': 'Mannitol', 'C': 'Dexamethasone', 'D': 'Acetazolamide'}'
[2025-09-29T14:31:44.576693] [PI] Starting research for query: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
All are drugs which lower IOP except 

Options:
{'A': 'Clonidine', 'B': 'Mannitol', 'C': 'Dexamethasone', 'D': 'Acetazolamide'}'
[2025-09-29T14:31:44.578183] Saving text to bench_final/run1/medmcqa/medmcqa_94/pi_initial_prompt.txt
[2025-09-29T14:31:44.585548] [PI] Calling o3 for initial analysis...
[2025-09-29T14:31:50.616145] [PI] Reasoning iteration 1
[2025-09-29T14:31:50.617747] [PI reasoning] **Determining drug effects on IOP**

I'm figuring out which drugs don't lower intraocular pressure. Clonidine does lower IOP, as does Mannitol and Acetazolamide. Dexamethasone is interesting because it can actually increase IOP instead, potentially leading to glaucoma. So I think the answer should be Dexamethasone. I might want to include citations, but those could be more general knowledge. I'll definitely need to confirm this with some additional search to get the right references!
[2025-09-29T14:31:50.620762] [PI] Executing function call 1: hybrid_search
[2025-09-29T14:31:50.622487] [PI] Function arguments: {'query': 'dexamethasone increases intraocular pressure corticosteroid induced ocular hypertension', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-09-29T14:31:50.631670] Saving JSON to bench_final/run1/medmcqa/medmcqa_94/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-09-29T14:32:48.147496] [PI] Function hybrid_search executed successfully
[2025-09-29T14:32:48.151816] Saving JSON to bench_final/run1/medmcqa/medmcqa_94/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-09-29T14:32:48.170835] [PI] Continuing reasoning with 1 function responses...
[2025-09-29T14:32:52.782472] [PI] Reasoning iteration 2
[2025-09-29T14:32:52.784085] [PI] Executing function call 1: hybrid_search
[2025-09-29T14:32:52.786926] [PI] Function arguments: {'query': 'clonidine intraocular pressure', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-09-29T14:32:52.788396] Saving JSON to bench_final/run1/medmcqa/medmcqa_94/pi_iteration_2_tool_call_2_hybrid_search.json
[2025-09-29T14:33:23.231515] [PI] Function hybrid_search executed successfully
[2025-09-29T14:33:23.232525] Saving JSON to bench_final/run1/medmcqa/medmcqa_94/pi_iteration_2_tool_result_2_hybrid_search.json
[2025-09-29T14:33:23.243238] [PI] Continuing reasoning with 1 function responses...
[2025-09-29T14:33:28.132176] [PI] Reasoning iteration 3
[2025-09-29T14:33:28.133786] [PI] Executing function call 1: hybrid_search
[2025-09-29T14:33:28.136149] [PI] Function arguments: {'query': 'mannitol intravenous lowers intraocular pressure osmotic agent glaucoma', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-09-29T14:33:28.137801] Saving JSON to bench_final/run1/medmcqa/medmcqa_94/pi_iteration_3_tool_call_2_hybrid_search.json
[2025-09-29T14:34:07.287828] [PI] Function hybrid_search executed successfully
[2025-09-29T14:34:07.293592] Saving JSON to bench_final/run1/medmcqa/medmcqa_94/pi_iteration_3_tool_result_2_hybrid_search.json
[2025-09-29T14:34:07.321635] [PI] Continuing reasoning with 1 function responses...
[2025-09-29T14:34:10.320401] [PI] Reasoning iteration 4
[2025-09-29T14:34:10.322551] [PI] Executing function call 1: hybrid_search
[2025-09-29T14:34:10.323967] [PI] Function arguments: {'query': 'acetazolamide lowers intraocular pressure glaucoma', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-09-29T14:34:10.327075] Saving JSON to bench_final/run1/medmcqa/medmcqa_94/pi_iteration_4_tool_call_2_hybrid_search.json
[2025-09-29T14:35:06.770589] [PI] Function hybrid_search executed successfully
[2025-09-29T14:35:06.772405] Saving JSON to bench_final/run1/medmcqa/medmcqa_94/pi_iteration_4_tool_result_2_hybrid_search.json
[2025-09-29T14:35:06.782225] [PI] Continuing reasoning with 1 function responses...
[2025-09-29T14:35:17.171360] [PI] Reasoning iteration 5
[2025-09-29T14:35:17.173071] [PI] No function calls found in response
[2025-09-29T14:35:17.178626] [PI] No more function calls - research complete
[2025-09-29T14:35:17.180786] Saving text to bench_final/run1/medmcqa/medmcqa_94/pi_final_answer.txt
[2025-09-29T14:35:17.188050] [QUERYOME] Query completed successfully
