D

Mannitol (osmotic diuretic), methazolamide (carbonic-anhydrase inhibitor), and clonidine (topical α2-agonist) are all documented to lower intraocular pressure in glaucoma patients or models [Johnson 2015 PMID 25844506; Xu 1999 PMID 11835778; Harrison 1977 PMID 889511]. In contrast, dexamethasone—a corticosteroid—typically raises, rather than lowers, intraocular pressure and can precipitate steroid-induced glaucoma [Weinreb 1985 PMID 4038695].