[2025-09-30T19:33:28.267513] [QUERYOME] Starting research for query 858: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
A 23-year-old lady taking antiepileptics for a seizure disorder gets married. When should folic acid supplementation advised to the patient? 

Options:
{'A': 'Any time as soon as she presents to the clinic irrespective of pregnancy', 'B': 'Three months before becoming pregnant', 'C': '1st trimester', 'D': 'As soon as pregnancy is confirmed'}'
[2025-09-30T19:33:28.346332] [PI] Starting research for query: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
A 23-year-old lady taking antiepileptics for a seizure disorder gets married. When should folic acid supplementation advised to the patient? 

Options:
{'A': 'Any time as soon as she presents to the clinic irrespective of pregnancy', 'B': 'Three months before becoming pregnant', 'C': '1st trimester', 'D': 'As soon as pregnancy is confirmed'}'
[2025-09-30T19:33:28.353508] Saving text to bench_final/run1/medmcqa/medmcqa_857/pi_initial_prompt.txt
[2025-09-30T19:33:28.359371] [PI] Calling o3 for initial analysis...
[2025-09-30T19:33:32.131073] [PI] Reasoning iteration 1
[2025-09-30T19:33:32.141807] [PI reasoning] **Searching for information on antiepileptics**

I need to provide an answer about the teratogenic risks associated with antiepileptic drugs and the importance of high-dose folic acid for women considering pregnancy. The best practice is to recommend starting high-dose folic acid at least three months before conception. I'll confirm this with a quick search to find the necessary citations and references to support this guidance.
[2025-09-30T19:33:32.144993] [PI] Executing function call 1: hybrid_search
[2025-09-30T19:33:32.147577] [PI] Function arguments: {'query': 'women with epilepsy folic acid supplementation three months before conception neural tube defect', 'k': 10, 'faiss_weight': 0.4, 'bm25_weight': 0.6, 'use_rrf': True}
[2025-09-30T19:33:32.151576] Saving JSON to bench_final/run1/medmcqa/medmcqa_857/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-09-30T19:34:36.612896] [PI] Function hybrid_search executed successfully
[2025-09-30T19:34:36.625575] Saving JSON to bench_final/run1/medmcqa/medmcqa_857/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-09-30T19:34:36.638119] [PI] Continuing reasoning with 1 function responses...
[2025-09-30T19:34:50.446964] [PI] Reasoning iteration 2
[2025-09-30T19:34:50.452124] [PI] No function calls found in response
[2025-09-30T19:34:50.453745] [PI] No more function calls - research complete
[2025-09-30T19:34:50.456385] Saving text to bench_final/run1/medmcqa/medmcqa_857/pi_final_answer.txt
[2025-09-30T19:34:50.463550] [QUERYOME] Query completed successfully
