B

Nucleolar-pattern ANA is strongly linked to systemic sclerosis; patients typically develop the “CREST”/scleroderma spectrum of features such as sclerodactyly, Raynaud’s phenomenon and esophageal dysmotility rather than SLE, Sjögren’s or Behçet-like mucosal ulcers [Reimer et al., 1988, PMID 2451921; Błaszczyk et al., 1990, PMID 2128868].