B

Crigler-Najjar syndrome, Gilbert syndrome, and hemolytic anemia all cause predominantly unconjugated (indirect) hyperbilirubinemia, whereas Dubin-Johnson syndrome is characterized by impaired hepatic excretion of conjugated bilirubin, leading to a rise in the conjugated (direct) fraction, not the unconjugated fraction [Hollander, 1981, PMID 6994579].