[2025-09-30T06:46:03.936605] [QUERYOME] Starting research for query 545: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Calcium ions triggers muscle contraction by binding to: 

Options:
{'A': 'Actin', 'B': 'Myosin', 'C': 'Troponin', 'D': 'Tropomyosin'}'
[2025-09-30T06:46:04.015671] [PI] Starting research for query: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Calcium ions triggers muscle contraction by binding to: 

Options:
{'A': 'Actin', 'B': 'Myosin', 'C': 'Troponin', 'D': 'Tropomyosin'}'
[2025-09-30T06:46:04.022598] Saving text to bench_final/run1/medmcqa/medmcqa_544/pi_initial_prompt.txt
[2025-09-30T06:46:04.028658] [PI] Calling o3 for initial analysis...
[2025-09-30T06:46:09.619727] [PI] Reasoning iteration 1
[2025-09-30T06:46:09.623975] [PI reasoning] **Considering evidence for Troponin**

I should focus on answering the question simply, likely by stating "Troponin." I want to ensure I back this up with reliable evidence from standard physiology. A quick search will help me gather the necessary sources to support my answer. This way, I can provide a clear and concise response that explains why Troponin is relevant while ensuring I'm well-supported with evidence. Let's get started on that!
[2025-09-30T06:46:09.625596] [PI] Executing function call 1: hybrid_search
[2025-09-30T06:46:09.629954] [PI] Function arguments: {'query': 'calcium ions bind to troponin to initiate skeletal muscle contraction', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-09-30T06:46:09.631452] Saving JSON to bench_final/run1/medmcqa/medmcqa_544/pi_iteration_1_tool_call_5_hybrid_search.json
[2025-09-30T06:46:38.816509] [PI] Function hybrid_search executed successfully
[2025-09-30T06:46:38.818989] Saving JSON to bench_final/run1/medmcqa/medmcqa_544/pi_iteration_1_tool_result_5_hybrid_search.json
[2025-09-30T06:46:38.826415] [PI] Continuing reasoning with 1 function responses...
[2025-09-30T06:46:42.544319] [PI] Reasoning iteration 2
[2025-09-30T06:46:42.550699] [PI] No function calls found in response
[2025-09-30T06:46:42.554596] [PI] No more function calls - research complete
[2025-09-30T06:46:42.559341] Saving text to bench_final/run1/medmcqa/medmcqa_544/pi_final_answer.txt
[2025-09-30T06:46:42.569039] [QUERYOME] Query completed successfully
