[2025-10-02T09:45:26.638732] [QUERYOME] Starting research for query 2535: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
A 28 years old female presented with the history of recurrent aboions, pain in calves for 4 years. Patient is suffering from congenital deficiency of:

Options:
A. Protein C
B. Thrombin
C. Plasmin
D. Factor XIII'
[2025-10-02T09:45:26.678002] [PI] Starting research for query: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
A 28 years old female presented with the history of recurrent aboions, pain in calves for 4 years. Patient is suffering from congenital deficiency of:

Options:
A. Protein C
B. Thrombin
C. Plasmin
D. Factor XIII'
[2025-10-02T09:45:26.680803] Saving text to bench_final/run1/medmcqa/medmcqa_4095/pi_initial_prompt.txt
[2025-10-02T09:45:26.686218] [PI] Calling o3 for initial analysis...
[2025-10-02T09:45:31.781820] [PI] Reasoning iteration 1
[2025-10-02T09:45:31.785167] [PI] Executing function call 1: hybrid_search
[2025-10-02T09:45:31.786883] [PI] Function arguments: {'query': 'protein C deficiency recurrent pregnancy loss venous thrombosis calf pain', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-02T09:45:31.789036] Saving JSON to bench_final/run1/medmcqa/medmcqa_4095/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-10-02T09:45:32.407851] [PI] Function hybrid_search executed successfully
[2025-10-02T09:45:32.412447] Saving JSON to bench_final/run1/medmcqa/medmcqa_4095/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-10-02T09:45:32.431726] [PI] Continuing reasoning with 1 function responses...
[2025-10-02T09:45:36.911132] [PI] Reasoning iteration 2
[2025-10-02T09:45:36.912748] [PI] Executing function call 1: hybrid_search
[2025-10-02T09:45:36.915838] [PI] Function arguments: {'query': 'factor XIII deficiency recurrent miscarriages', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-02T09:45:36.917579] Saving JSON to bench_final/run1/medmcqa/medmcqa_4095/pi_iteration_2_tool_call_2_hybrid_search.json
[2025-10-02T09:45:37.408247] [PI] Function hybrid_search executed successfully
[2025-10-02T09:45:37.411978] Saving JSON to bench_final/run1/medmcqa/medmcqa_4095/pi_iteration_2_tool_result_2_hybrid_search.json
[2025-10-02T09:45:37.417906] [PI] Continuing reasoning with 1 function responses...
[2025-10-02T09:45:47.747581] [PI] Reasoning iteration 3
[2025-10-02T09:45:47.749121] [PI reasoning] **Crafting a concise response**

I need to focus on providing evidence supporting the reasoning about Protein C deficiency leading to recurrent fetal loss and thrombosis. The relevant articles I've identified are from Richards 1997 and Bonnar 1999, highlighting the associated risks. My reasoning shows that recurrent abortions, along with calf pain, suggest thrombosis due to thrombophilia, specifically Protein C deficiency. It's important to clarify that Factor XIII isn't linked to thrombosis but rather bleeding. I’ll include citations from both articles to strengthen the response.
[2025-10-02T09:45:47.752186] [PI] No function calls found in response
[2025-10-02T09:45:47.753805] [PI] No more function calls - research complete
[2025-10-02T09:45:47.756686] Saving text to bench_final/run1/medmcqa/medmcqa_4095/pi_final_answer.txt
[2025-10-02T09:45:47.762578] [QUERYOME] Query completed successfully
