[2025-10-02T09:29:23.246497] [QUERYOME] Starting research for query 2508: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
Which of the following is done for screening of Down's syndrome in first trimester?

Options:
A. Beta HCG and PAPP-A
B. Unconjugated estradiol and PAPPA
C. AFP and Inhibin A
D. AFP and Beta HCG'
[2025-10-02T09:29:23.308161] [PI] Starting research for query: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
Which of the following is done for screening of Down's syndrome in first trimester?

Options:
A. Beta HCG and PAPP-A
B. Unconjugated estradiol and PAPPA
C. AFP and Inhibin A
D. AFP and Beta HCG'
[2025-10-02T09:29:23.312319] Saving text to bench_final/run1/medmcqa/medmcqa_4068/pi_initial_prompt.txt
[2025-10-02T09:29:23.317092] [PI] Calling o3 for initial analysis...
[2025-10-02T09:29:26.966697] [PI] Reasoning iteration 1
[2025-10-02T09:29:26.968126] [PI] Executing function call 1: hybrid_search
[2025-10-02T09:29:26.970821] [PI] Function arguments: {'query': 'first trimester screening Down syndrome PAPP-A free beta hCG first trimester combined test', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-02T09:29:26.973046] Saving JSON to bench_final/run1/medmcqa/medmcqa_4068/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-10-02T09:29:27.608250] [PI] Function hybrid_search executed successfully
[2025-10-02T09:29:27.611849] Saving JSON to bench_final/run1/medmcqa/medmcqa_4068/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-10-02T09:29:27.624663] [PI] Continuing reasoning with 1 function responses...
[2025-10-02T09:29:32.198288] [PI] Reasoning iteration 2
[2025-10-02T09:29:32.199564] [PI] No function calls found in response
[2025-10-02T09:29:32.211670] [PI] No more function calls - research complete
[2025-10-02T09:29:32.213319] Saving text to bench_final/run1/medmcqa/medmcqa_4068/pi_final_answer.txt
[2025-10-02T09:29:32.233096] [QUERYOME] Query completed successfully
