[2025-10-02T01:40:55.810418] [QUERYOME] Starting research for query 1478: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
In uncontrolled diabetes mellitus, elevated triglyceride and VLDL levels are seen due to:

Options:
A. Increased activity of lipoprotein lipase and decreased activity of hormone sensitive lipase
B. Increased activity of hormone sensitive lipase and decreased activity of lipoprotein lipase
C. Increase in peripheral LDL receptors
D. Increased activity of hepatic lipase'
[2025-10-02T01:40:55.850780] [PI] Starting research for query: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
In uncontrolled diabetes mellitus, elevated triglyceride and VLDL levels are seen due to:

Options:
A. Increased activity of lipoprotein lipase and decreased activity of hormone sensitive lipase
B. Increased activity of hormone sensitive lipase and decreased activity of lipoprotein lipase
C. Increase in peripheral LDL receptors
D. Increased activity of hepatic lipase'
[2025-10-02T01:40:55.852441] Saving text to bench_final/run1/medmcqa/medmcqa_3038/pi_initial_prompt.txt
[2025-10-02T01:40:55.856805] [PI] Calling o3 for initial analysis...
[2025-10-02T01:41:00.066363] [PI] Reasoning iteration 1
[2025-10-02T01:41:00.067878] [PI] Executing function call 1: hybrid_search
[2025-10-02T01:41:00.069106] [PI] Function arguments: {'query': 'uncontrolled diabetes mellitus elevated triglycerides increased hormone sensitive lipase decreased lipoprotein lipase VLDL', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-02T01:41:00.070121] Saving JSON to bench_final/run1/medmcqa/medmcqa_3038/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-10-02T01:41:01.010125] [PI] Function hybrid_search executed successfully
[2025-10-02T01:41:01.012207] Saving JSON to bench_final/run1/medmcqa/medmcqa_3038/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-10-02T01:41:01.018074] [PI] Continuing reasoning with 1 function responses...
[2025-10-02T01:41:04.093258] [PI] Reasoning iteration 2
[2025-10-02T01:41:04.095914] [PI] Executing function call 1: hybrid_search
[2025-10-02T01:41:04.097826] [PI] Function arguments: {'query': 'insulin deficiency increases hormone sensitive lipase adipose tissue diabetes', 'k': 10, 'faiss_weight': 0.7, 'bm25_weight': 0.3, 'use_rrf': True}
[2025-10-02T01:41:04.106409] Saving JSON to bench_final/run1/medmcqa/medmcqa_3038/pi_iteration_2_tool_call_2_hybrid_search.json
[2025-10-02T01:41:05.473426] [PI] Function hybrid_search executed successfully
[2025-10-02T01:41:05.476126] Saving JSON to bench_final/run1/medmcqa/medmcqa_3038/pi_iteration_2_tool_result_2_hybrid_search.json
[2025-10-02T01:41:05.495107] [PI] Continuing reasoning with 1 function responses...
[2025-10-02T01:41:11.463835] [PI] Reasoning iteration 3
[2025-10-02T01:41:11.468683] [PI] No function calls found in response
[2025-10-02T01:41:11.470820] [PI] No more function calls - research complete
[2025-10-02T01:41:11.472280] Saving text to bench_final/run1/medmcqa/medmcqa_3038/pi_final_answer.txt
[2025-10-02T01:41:11.476459] [QUERYOME] Query completed successfully
