[2025-10-02T01:03:40.213609] [QUERYOME] Starting research for query 1394: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
Physiological active form of cholesterol is:

Options:
A. Lipoprotein
B. Lipid
C. Free cholesterol
D. None of the above'
[2025-10-02T01:03:40.265156] [PI] Starting research for query: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
Physiological active form of cholesterol is:

Options:
A. Lipoprotein
B. Lipid
C. Free cholesterol
D. None of the above'
[2025-10-02T01:03:40.266908] Saving text to bench_final/run1/medmcqa/medmcqa_2954/pi_initial_prompt.txt
[2025-10-02T01:03:40.271550] [PI] Calling o3 for initial analysis...
[2025-10-02T01:03:46.211817] [PI] Reasoning iteration 1
[2025-10-02T01:03:46.213326] [PI reasoning] **Identifying active cholesterol form**

I'm figuring out the answer to a question about the physiologically active form of cholesterol. The options are lipoprotein, lipid, free cholesterol, or none. Based on what I know, cholesterol is found in plasma bound to lipoproteins, but the free (unesterified) cholesterol is likely the active form used by cell membranes. I think the best answer is C: free cholesterol. Now, I need to quickly find supporting evidence.
[2025-10-02T01:03:46.215991] [PI] Executing function call 1: hybrid_search
[2025-10-02T01:03:46.218422] [PI] Function arguments: {'query': 'free (unesterified) cholesterol is the biologically active form', 'k': 5, 'faiss_weight': 0.7, 'bm25_weight': 0.3, 'use_rrf': True}
[2025-10-02T01:03:46.220457] Saving JSON to bench_final/run1/medmcqa/medmcqa_2954/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-10-02T01:03:47.138324] [PI] Function hybrid_search executed successfully
[2025-10-02T01:03:47.140737] Saving JSON to bench_final/run1/medmcqa/medmcqa_2954/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-10-02T01:03:47.147484] [PI] Continuing reasoning with 1 function responses...
[2025-10-02T01:03:50.150395] [PI] Reasoning iteration 2
[2025-10-02T01:03:50.152738] [PI] Executing function call 1: bm25_mesh_terms_search
[2025-10-02T01:03:50.155106] [PI] Function arguments: {'query': 'Cholesterol, unesterified', 'k': 10}
[2025-10-02T01:03:50.156529] Saving JSON to bench_final/run1/medmcqa/medmcqa_2954/pi_iteration_2_tool_call_2_bm25_mesh_terms_search.json
[2025-10-02T01:03:50.695840] [PI] Function bm25_mesh_terms_search executed successfully
[2025-10-02T01:03:50.697744] Saving JSON to bench_final/run1/medmcqa/medmcqa_2954/pi_iteration_2_tool_result_2_bm25_mesh_terms_search.json
[2025-10-02T01:03:50.709457] [PI] Continuing reasoning with 1 function responses...
[2025-10-02T01:03:58.281684] [PI] Reasoning iteration 3
[2025-10-02T01:03:58.283241] [PI] Executing function call 1: hybrid_search
[2025-10-02T01:03:58.285389] [PI] Function arguments: {'query': 'biologically active free cholesterol form', 'k': 5, 'faiss_weight': 0.8, 'bm25_weight': 0.2, 'use_rrf': True}
[2025-10-02T01:03:58.287192] Saving JSON to bench_final/run1/medmcqa/medmcqa_2954/pi_iteration_3_tool_call_2_hybrid_search.json
[2025-10-02T01:03:59.147060] [PI] Function hybrid_search executed successfully
[2025-10-02T01:03:59.148696] Saving JSON to bench_final/run1/medmcqa/medmcqa_2954/pi_iteration_3_tool_result_2_hybrid_search.json
[2025-10-02T01:03:59.206609] [PI] Continuing reasoning with 1 function responses...
[2025-10-02T01:04:06.971562] [PI] Reasoning iteration 4
[2025-10-02T01:04:06.972951] [PI] No function calls found in response
[2025-10-02T01:04:06.974946] [PI] No more function calls - research complete
[2025-10-02T01:04:06.976625] Saving text to bench_final/run1/medmcqa/medmcqa_2954/pi_final_answer.txt
[2025-10-02T01:04:06.980829] [QUERYOME] Query completed successfully
