[2025-09-29T12:28:11.527882] [QUERYOME] Starting research for query 30: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Release of synaptic vesicle from presynaptic terminal is inhibited by 

Options:
{'A': 'Inhibition of conduction of nerve impulse', 'B': 'Prevention of sodium influx', 'C': 'Prevention of calcium influx', 'D': 'Prevention of depolarization of nerve terminal'}'
[2025-09-29T12:28:11.574713] [PI] Starting research for query: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Release of synaptic vesicle from presynaptic terminal is inhibited by 

Options:
{'A': 'Inhibition of conduction of nerve impulse', 'B': 'Prevention of sodium influx', 'C': 'Prevention of calcium influx', 'D': 'Prevention of depolarization of nerve terminal'}'
[2025-09-29T12:28:11.590487] Saving text to bench_final/run1/medmcqa/medmcqa_29/pi_initial_prompt.txt
[2025-09-29T12:28:11.595871] [PI] Calling o3 for initial analysis...
[2025-09-29T12:28:16.347005] [PI] Reasoning iteration 1
[2025-09-29T12:28:16.348536] [PI] Executing function call 1: hybrid_search
[2025-09-29T12:28:16.350782] [PI] Function arguments: {'query': 'presynaptic calcium influx required for synaptic vesicle release', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-09-29T12:28:16.353507] Saving JSON to bench_final/run1/medmcqa/medmcqa_29/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-09-29T12:28:56.308474] [PI] Function hybrid_search executed successfully
[2025-09-29T12:28:56.310189] Saving JSON to bench_final/run1/medmcqa/medmcqa_29/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-09-29T12:28:56.333070] [PI] Continuing reasoning with 1 function responses...
[2025-09-29T12:28:59.810310] [PI] Reasoning iteration 2
[2025-09-29T12:28:59.812724] [PI] No function calls found in response
[2025-09-29T12:28:59.814266] [PI] No more function calls - research complete
[2025-09-29T12:28:59.817587] Saving text to bench_final/run1/medmcqa/medmcqa_29/pi_final_answer.txt
[2025-09-29T12:28:59.824289] [QUERYOME] Query completed successfully
