A

Evidence-based medicine is defined as the conscientious integration of the best current research evidence with clinical expertise and patient values; while decision-analysis models can be helpful, they are not the basis on which EBM “depends,” making option A incorrect (Sarasin 1999, PMID 10542307; Montori & Guyatt 2001, PMID 11679142).  
EBM indeed emphasizes formal critical appraisal of published research (B), ranks systematic reviews/meta-analyses of well-conducted RCTs as the strongest therapeutic evidence (Wright 2007, PMID 17279036), and places expert opinion at the bottom of the evidence hierarchy (Tonelli 1999, PMID 10587679); therefore options B, C and D are true.