[2025-09-29T19:27:49.000012] [QUERYOME] Starting research for query 218: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Which of the following lipoproteins does not move towards charged end in electrophoresis? 

Options:
{'A': 'VLDL', 'B': 'LDL', 'C': 'HDL', 'D': 'Chylomicrons'}'
[2025-09-29T19:27:49.092364] [PI] Starting research for query: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Which of the following lipoproteins does not move towards charged end in electrophoresis? 

Options:
{'A': 'VLDL', 'B': 'LDL', 'C': 'HDL', 'D': 'Chylomicrons'}'
[2025-09-29T19:27:49.093876] Saving text to bench_final/run1/medmcqa/medmcqa_217/pi_initial_prompt.txt
[2025-09-29T19:27:49.098953] [PI] Calling o3 for initial analysis...
[2025-09-29T19:27:55.915080] [PI] Reasoning iteration 1
[2025-09-29T19:27:55.918147] [PI reasoning] **Determining lipoprotein mobility**

I need to answer which lipoprotein does not move towards the charged end in electrophoresis. Essentially, I'm looking for the least mobile one. In lipoprotein electrophoresis, chylomicrons stay at the origin and don't migrate since they’re the largest. Beta-lipoproteins (LDL) move, as do pre-beta-lipoproteins (VLDL) and alpha-lipoproteins (HDL) to varying degrees. Since chylomicrons don’t move at all, the answer is D: Chylomicrons. I'll consider looking up some evidence for this as well.
[2025-09-29T19:27:55.919869] [PI] Executing function call 1: hybrid_search
[2025-09-29T19:27:55.922559] [PI] Function arguments: {'query': 'lipoprotein electrophoresis chylomicrons remain at origin do not migrate', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-09-29T19:27:55.924100] Saving JSON to bench_final/run1/medmcqa/medmcqa_217/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-09-29T19:28:52.718831] [PI] Function hybrid_search executed successfully
[2025-09-29T19:28:52.720601] Saving JSON to bench_final/run1/medmcqa/medmcqa_217/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-09-29T19:28:52.729952] [PI] Continuing reasoning with 1 function responses...
[2025-09-29T19:28:55.961207] [PI] Reasoning iteration 2
[2025-09-29T19:28:55.963685] [PI] Executing function call 1: hybrid_search
[2025-09-29T19:28:55.965395] [PI] Function arguments: {'query': 'agarose lipoprotein electrophoresis chylomicrons remain at origin', 'k': 10, 'faiss_weight': 0.4, 'bm25_weight': 0.6, 'use_rrf': True}
[2025-09-29T19:28:55.967695] Saving JSON to bench_final/run1/medmcqa/medmcqa_217/pi_iteration_2_tool_call_2_hybrid_search.json
[2025-09-29T19:29:53.700646] [PI] Function hybrid_search executed successfully
[2025-09-29T19:29:53.710440] Saving JSON to bench_final/run1/medmcqa/medmcqa_217/pi_iteration_2_tool_result_2_hybrid_search.json
[2025-09-29T19:29:53.719308] [PI] Continuing reasoning with 1 function responses...
[2025-09-29T19:29:59.624861] [PI] Reasoning iteration 3
[2025-09-29T19:29:59.628060] [PI] No function calls found in response
[2025-09-29T19:29:59.629691] [PI] No more function calls - research complete
[2025-09-29T19:29:59.630767] Saving text to bench_final/run1/medmcqa/medmcqa_217/pi_final_answer.txt
[2025-09-29T19:29:59.635822] [QUERYOME] Query completed successfully
