[2025-10-01T18:27:08.695005] [QUERYOME] Starting research for query 463: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
A Middle aged woman presents with fissures in mouth, tingling sensation and peripheral neuropathy. Investigations showed reduced glutathione reductase activity. which vitamin deficiency is the likely cause of this?

Options:
A. Vitamin B1
B. Vitamin 82
C. Vitamin 86
D. Vitamin B l2'
[2025-10-01T18:27:08.738090] [PI] Starting research for query: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
A Middle aged woman presents with fissures in mouth, tingling sensation and peripheral neuropathy. Investigations showed reduced glutathione reductase activity. which vitamin deficiency is the likely cause of this?

Options:
A. Vitamin B1
B. Vitamin 82
C. Vitamin 86
D. Vitamin B l2'
[2025-10-01T18:27:08.740741] Saving text to bench_final/run1/medmcqa/medmcqa_2023/pi_initial_prompt.txt
[2025-10-01T18:27:08.746039] [PI] Calling o3 for initial analysis...
[2025-10-01T18:27:16.118207] [PI] Reasoning iteration 1
[2025-10-01T18:27:16.119727] [PI reasoning] **Confirming vitamin deficiency impact**

I’m looking at a question about deficiency causing reduced glutathione reductase activity, with symptoms like mouth fissures, tingling, and peripheral neuropathy. The options are B1, B2, B6, and B12. Since glutathione reductase requires FAD from riboflavin (B2), that makes riboflavin the likely cause. Symptoms like cheilosis and neuropathy support this. I know I should confirm this, but I won’t need a complex search; a simple search for data on riboflavin deficiency will do.
[2025-10-01T18:27:16.122104] [PI] Executing function call 1: hybrid_search
[2025-10-01T18:27:16.123368] [PI] Function arguments: {'query': 'erythrocyte glutathione reductase activity indicator of riboflavin deficiency', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T18:27:16.125384] Saving JSON to bench_final/run1/medmcqa/medmcqa_2023/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-10-01T18:27:17.129657] [PI] Function hybrid_search executed successfully
[2025-10-01T18:27:17.132411] Saving JSON to bench_final/run1/medmcqa/medmcqa_2023/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-10-01T18:27:17.138420] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T18:27:21.108823] [PI] Reasoning iteration 2
[2025-10-01T18:27:21.110960] [PI] No function calls found in response
[2025-10-01T18:27:21.112259] [PI] No more function calls - research complete
[2025-10-01T18:27:21.113697] Saving text to bench_final/run1/medmcqa/medmcqa_2023/pi_final_answer.txt
[2025-10-01T18:27:21.118248] [QUERYOME] Query completed successfully
