[2025-10-01T17:45:56.848076] [QUERYOME] Starting research for query 360: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
A child born with multiple congenital defect including cleft palate, neural tube defect, atrial septal defect and microcephaly which of the following drug is used by mother during pregnancy:

Options:
A. Erythromycin
B. Isotretinoin
C. Ibuprofen
D. Metronidazole'
[2025-10-01T17:45:56.887743] [PI] Starting research for query: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
A child born with multiple congenital defect including cleft palate, neural tube defect, atrial septal defect and microcephaly which of the following drug is used by mother during pregnancy:

Options:
A. Erythromycin
B. Isotretinoin
C. Ibuprofen
D. Metronidazole'
[2025-10-01T17:45:56.889237] Saving text to bench_final/run1/medmcqa/medmcqa_1920/pi_initial_prompt.txt
[2025-10-01T17:45:56.894297] [PI] Calling o3 for initial analysis...
[2025-10-01T17:46:01.462946] [PI] Reasoning iteration 1
[2025-10-01T17:46:01.465735] [PI] Executing function call 1: hybrid_search
[2025-10-01T17:46:01.466719] [PI] Function arguments: {'query': 'isotretinoin embryopathy cleft palate neural tube defect heart defects microcephaly retinoic acid teratogenicity', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T17:46:01.468738] Saving JSON to bench_final/run1/medmcqa/medmcqa_1920/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-10-01T17:46:03.471786] [PI] Function hybrid_search executed successfully
[2025-10-01T17:46:03.473076] Saving JSON to bench_final/run1/medmcqa/medmcqa_1920/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-10-01T17:46:03.479613] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T17:46:10.951182] [PI] Reasoning iteration 2
[2025-10-01T17:46:10.953066] [PI] No function calls found in response
[2025-10-01T17:46:10.954625] [PI] No more function calls - research complete
[2025-10-01T17:46:10.957828] Saving text to bench_final/run1/medmcqa/medmcqa_1920/pi_final_answer.txt
[2025-10-01T17:46:10.986208] [QUERYOME] Query completed successfully
