[2025-09-29T11:54:46.866907] [QUERYOME] Starting research for query 19: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
A G3P2, pregnant comes to your clinic at 18 weeks of gestation for genetic counselling. She has a history of two kids born with thalassemia major. Which test would you recommend now? 

Options:
{'A': 'Amniocentesis', 'B': 'Chorionic villus sampling', 'C': 'Cordocentesis', 'D': 'Non-invasive prenatal testing'}'
[2025-09-29T11:54:46.926973] [PI] Starting research for query: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
A G3P2, pregnant comes to your clinic at 18 weeks of gestation for genetic counselling. She has a history of two kids born with thalassemia major. Which test would you recommend now? 

Options:
{'A': 'Amniocentesis', 'B': 'Chorionic villus sampling', 'C': 'Cordocentesis', 'D': 'Non-invasive prenatal testing'}'
[2025-09-29T11:54:46.928670] Saving text to bench_final/run1/medmcqa/medmcqa_18/pi_initial_prompt.txt
[2025-09-29T11:54:46.933941] [PI] Calling o3 for initial analysis...
[2025-09-29T11:54:56.239071] [PI] Reasoning iteration 1
[2025-09-29T11:54:56.242051] [PI reasoning] **Assessing prenatal testing options**

I'm considering the situation: at 18 weeks gestation, with a history of thalassemia major in previous children. The recommended test now would be amniocentesis, which is typically performed between 16-18 weeks to test for genetic disorders like thalassemia. CVS would be too late, and while cordocentesis is an option, it's more invasive. I should look up guidelines to support this conclusion and ensure I provide concise reasoning.
[2025-09-29T11:54:56.251511] [PI] Executing function call 1: hybrid_search
[2025-09-29T11:54:56.252696] [PI] Function arguments: {'query': 'amniocentesis 16 weeks prenatal diagnosis thalassemia major', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-09-29T11:54:56.259718] Saving JSON to bench_final/run1/medmcqa/medmcqa_18/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-09-29T11:55:50.408821] [PI] Function hybrid_search executed successfully
[2025-09-29T11:55:50.411546] Saving JSON to bench_final/run1/medmcqa/medmcqa_18/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-09-29T11:55:50.417646] [PI] Continuing reasoning with 1 function responses...
[2025-09-29T11:55:54.217614] [PI] Reasoning iteration 2
[2025-09-29T11:55:54.219149] [PI] Executing function call 1: hybrid_search
[2025-09-29T11:55:54.221810] [PI] Function arguments: {'query': 'prenatal diagnosis hemoglobinopathies amniocentesis 15 20 weeks pregnancy', 'k': 5, 'faiss_weight': 0.5, 'bm25_weight': 0.5, 'use_rrf': True}
[2025-09-29T11:55:54.223205] Saving JSON to bench_final/run1/medmcqa/medmcqa_18/pi_iteration_2_tool_call_2_hybrid_search.json
[2025-09-29T11:56:52.976464] [PI] Function hybrid_search executed successfully
[2025-09-29T11:56:52.978229] Saving JSON to bench_final/run1/medmcqa/medmcqa_18/pi_iteration_2_tool_result_2_hybrid_search.json
[2025-09-29T11:56:52.993405] [PI] Continuing reasoning with 1 function responses...
[2025-09-29T11:56:57.622776] [PI] Reasoning iteration 3
[2025-09-29T11:56:57.624786] [PI] Executing function call 1: hybrid_search
[2025-09-29T11:56:57.627330] [PI] Function arguments: {'query': 'amniocentesis performed at 15 to 20 weeks american college obstetricians 2016 practice bulletin', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-09-29T11:56:57.629037] Saving JSON to bench_final/run1/medmcqa/medmcqa_18/pi_iteration_3_tool_call_2_hybrid_search.json
[2025-09-29T11:58:01.802681] [PI] Function hybrid_search executed successfully
[2025-09-29T11:58:01.811897] Saving JSON to bench_final/run1/medmcqa/medmcqa_18/pi_iteration_3_tool_result_2_hybrid_search.json
[2025-09-29T11:58:01.818021] [PI] Continuing reasoning with 1 function responses...
[2025-09-29T11:58:09.413726] [PI] Reasoning iteration 4
[2025-09-29T11:58:09.421659] [PI] No function calls found in response
[2025-09-29T11:58:09.423277] [PI] No more function calls - research complete
[2025-09-29T11:58:09.424743] Saving text to bench_final/run1/medmcqa/medmcqa_18/pi_final_answer.txt
[2025-09-29T11:58:09.431463] [QUERYOME] Query completed successfully
