[2025-10-01T16:42:31.343607] [QUERYOME] Starting research for query 232: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
What is the approved dose of misoprostol in emergent management of postpaum hemorrhage?

Options:
A. 200 mcg
B. 400 mcg
C. 600 mcg
D. 1000 mcg'
[2025-10-01T16:42:31.421695] [PI] Starting research for query: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
What is the approved dose of misoprostol in emergent management of postpaum hemorrhage?

Options:
A. 200 mcg
B. 400 mcg
C. 600 mcg
D. 1000 mcg'
[2025-10-01T16:42:31.423392] Saving text to bench_final/run1/medmcqa/medmcqa_1792/pi_initial_prompt.txt
[2025-10-01T16:42:31.429294] [PI] Calling o3 for initial analysis...
[2025-10-01T16:43:01.128470] [PI] Reasoning iteration 1
[2025-10-01T16:43:01.129733] [PI reasoning] **Considering misoprostol dosage**

I need to figure out the recommended dose of misoprostol for managing postpartum hemorrhage (PPH). WHO recommends 800 mcg sublingually as an alternative to IV oxytocin when necessary. Guidelines mention 600 mcg orally for prevention. But for emergent management, it’s 800 mcg sublingual. None of the options include 800 mcg, and while 1000 mcg is closest, it’s not recommended. Between 600 mcg and 1000 mcg, 600 is for prevention, not treatment. The exam likely expects the 800 mcg dosage.
[2025-10-01T16:43:01.132373] [PI] Executing function call 1: hybrid_search
[2025-10-01T16:43:01.133959] [PI] Function arguments: {'query': 'misoprostol 1000 micrograms rectal postpartum hemorrhage emergent management', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T16:43:01.138188] Saving JSON to bench_final/run1/medmcqa/medmcqa_1792/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-10-01T16:43:02.858033] [PI] Function hybrid_search executed successfully
[2025-10-01T16:43:02.861325] Saving JSON to bench_final/run1/medmcqa/medmcqa_1792/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-10-01T16:43:02.867775] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T16:43:12.739371] [PI] Reasoning iteration 2
[2025-10-01T16:43:12.742328] [PI] Executing function call 1: hybrid_search
[2025-10-01T16:43:12.744313] [PI] Function arguments: {'query': 'WHO 800 micrograms sublingual misoprostol postpartum hemorrhage treatment guideline', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T16:43:12.747081] Saving JSON to bench_final/run1/medmcqa/medmcqa_1792/pi_iteration_2_tool_call_2_hybrid_search.json
[2025-10-01T16:43:13.939338] [PI] Function hybrid_search executed successfully
[2025-10-01T16:43:13.943034] Saving JSON to bench_final/run1/medmcqa/medmcqa_1792/pi_iteration_2_tool_result_2_hybrid_search.json
[2025-10-01T16:43:13.951419] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T16:43:21.986763] [PI] Reasoning iteration 3
[2025-10-01T16:43:21.987786] [PI] Executing function call 1: hybrid_search
[2025-10-01T16:43:21.989899] [PI] Function arguments: {'query': 'ACOG practice bulletin postpartum hemorrhage misoprostol dosage 600 mcg', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T16:43:21.992842] Saving JSON to bench_final/run1/medmcqa/medmcqa_1792/pi_iteration_3_tool_call_2_hybrid_search.json
[2025-10-01T16:43:23.028380] [PI] Function hybrid_search executed successfully
[2025-10-01T16:43:23.031485] Saving JSON to bench_final/run1/medmcqa/medmcqa_1792/pi_iteration_3_tool_result_2_hybrid_search.json
[2025-10-01T16:43:23.038857] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T16:43:29.163410] [PI] Reasoning iteration 4
[2025-10-01T16:43:29.166265] [PI] Executing function call 1: hybrid_search
[2025-10-01T16:43:29.168344] [PI] Function arguments: {'query': 'FIGO misoprostol dosage postpartum hemorrhage treatment 600 micrograms', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T16:43:29.169913] Saving JSON to bench_final/run1/medmcqa/medmcqa_1792/pi_iteration_4_tool_call_2_hybrid_search.json
[2025-10-01T16:43:30.089140] [PI] Function hybrid_search executed successfully
[2025-10-01T16:43:30.092624] Saving JSON to bench_final/run1/medmcqa/medmcqa_1792/pi_iteration_4_tool_result_2_hybrid_search.json
[2025-10-01T16:43:30.098331] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T16:43:44.314194] [PI] Reasoning iteration 5
[2025-10-01T16:43:44.316599] [PI] Executing function call 1: hybrid_search
[2025-10-01T16:43:44.318573] [PI] Function arguments: {'query': 'rectal misoprostol 1000 µg postpartum hemorrhage guideline', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T16:43:44.321233] Saving JSON to bench_final/run1/medmcqa/medmcqa_1792/pi_iteration_5_tool_call_2_hybrid_search.json
[2025-10-01T16:43:44.768966] [PI] Function hybrid_search executed successfully
[2025-10-01T16:43:44.771856] Saving JSON to bench_final/run1/medmcqa/medmcqa_1792/pi_iteration_5_tool_result_2_hybrid_search.json
[2025-10-01T16:43:44.777769] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T16:43:52.814926] [PI] Reasoning iteration 6
[2025-10-01T16:43:52.817774] [PI] Executing function call 1: hybrid_search
[2025-10-01T16:43:52.819356] [PI] Function arguments: {'query': '600 microgram misoprostol emergent management postpartum hemorrhage', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T16:43:52.822338] Saving JSON to bench_final/run1/medmcqa/medmcqa_1792/pi_iteration_6_tool_call_2_hybrid_search.json
[2025-10-01T16:43:53.258385] [PI] Function hybrid_search executed successfully
[2025-10-01T16:43:53.261155] Saving JSON to bench_final/run1/medmcqa/medmcqa_1792/pi_iteration_6_tool_result_2_hybrid_search.json
[2025-10-01T16:43:53.267342] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T16:44:34.289069] [PI] Reasoning iteration 7
[2025-10-01T16:44:34.291793] [PI] No function calls found in response
[2025-10-01T16:44:34.293534] [PI] No more function calls - research complete
[2025-10-01T16:44:34.296318] Saving text to bench_final/run1/medmcqa/medmcqa_1792/pi_final_answer.txt
[2025-10-01T16:44:34.315209] [QUERYOME] Query completed successfully
