[2025-09-29T18:03:40.736596] [QUERYOME] Starting research for query 175: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Who discovered the structure and amino acid sequence of insulin as well as the interspecies differences in molecular structure and won the Nobel prize for? 

Options:
{'A': 'Prof. JJ Abel', 'B': 'Frederick Sanger', 'C': 'Rutter, Goodman and Uhlich', 'D': 'Frederick Banting and Charles Best'}'
[2025-09-29T18:03:40.774546] [PI] Starting research for query: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Who discovered the structure and amino acid sequence of insulin as well as the interspecies differences in molecular structure and won the Nobel prize for? 

Options:
{'A': 'Prof. JJ Abel', 'B': 'Frederick Sanger', 'C': 'Rutter, Goodman and Uhlich', 'D': 'Frederick Banting and Charles Best'}'
[2025-09-29T18:03:40.775768] Saving text to bench_final/run1/medmcqa/medmcqa_174/pi_initial_prompt.txt
[2025-09-29T18:03:40.779819] [PI] Calling o3 for initial analysis...
[2025-09-29T18:03:45.455517] [PI] Reasoning iteration 1
[2025-09-29T18:03:45.457076] [PI] Executing function call 1: hybrid_search
[2025-09-29T18:03:45.460228] [PI] Function arguments: {'query': 'Frederick Sanger insulin amino acid sequence Nobel Prize 1958', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-09-29T18:03:45.461665] Saving JSON to bench_final/run1/medmcqa/medmcqa_174/pi_iteration_1_tool_call_3_hybrid_search.json
[2025-09-29T18:04:43.776454] [PI] Function hybrid_search executed successfully
[2025-09-29T18:04:43.778055] Saving JSON to bench_final/run1/medmcqa/medmcqa_174/pi_iteration_1_tool_result_3_hybrid_search.json
[2025-09-29T18:04:43.785220] [PI] Continuing reasoning with 1 function responses...
[2025-09-29T18:04:48.186427] [PI] Reasoning iteration 2
[2025-09-29T18:04:48.188089] [PI] No function calls found in response
[2025-09-29T18:04:48.191388] [PI] No more function calls - research complete
[2025-09-29T18:04:48.193025] Saving text to bench_final/run1/medmcqa/medmcqa_174/pi_final_answer.txt
[2025-09-29T18:04:48.208045] [QUERYOME] Query completed successfully
