[2025-10-01T16:03:49.992280] [QUERYOME] Starting research for query 159: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
Which of the following is not done for antenatal diagnosis of Down's syndrome:

Options:
A. Amniotic fluid volume estimation
B. Alpha-fetoprotein estimation
C. Cordocentesis
D. Chorionic villous biopsy'
[2025-10-01T16:03:50.033112] [PI] Starting research for query: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
Which of the following is not done for antenatal diagnosis of Down's syndrome:

Options:
A. Amniotic fluid volume estimation
B. Alpha-fetoprotein estimation
C. Cordocentesis
D. Chorionic villous biopsy'
[2025-10-01T16:03:50.034572] Saving text to bench_final/run1/medmcqa/medmcqa_1719/pi_initial_prompt.txt
[2025-10-01T16:03:50.039746] [PI] Calling o3 for initial analysis...
[2025-10-01T16:03:56.263225] [PI] Reasoning iteration 1
[2025-10-01T16:03:56.264737] [PI reasoning] **Assessing antenatal tests**

I'm focusing on finding the single best option for antenatal diagnosis of Down syndrome. There are several diagnostic tests available, like maternal serum screening and procedures such as chorionic villus sampling and amniocentesis. Of these, I see that option A is the correct choice for this context. I think it’s important to gather citations for evidence, so I’m planning to search for guidelines related to prenatal diagnosis of Down syndrome. Let's get started on that!
[2025-10-01T16:03:56.267956] [PI] Executing function call 1: hybrid_search
[2025-10-01T16:03:56.269618] [PI] Function arguments: {'query': 'prenatal diagnosis of Down syndrome chorionic villus sampling amniocentesis cordocentesis serum alpha fetoprotein', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T16:03:56.272591] Saving JSON to bench_final/run1/medmcqa/medmcqa_1719/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-10-01T16:03:59.593347] [PI] Function hybrid_search executed successfully
[2025-10-01T16:03:59.596499] Saving JSON to bench_final/run1/medmcqa/medmcqa_1719/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-10-01T16:03:59.611405] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T16:04:13.954459] [PI] Reasoning iteration 2
[2025-10-01T16:04:13.956599] [PI] No function calls found in response
[2025-10-01T16:04:13.958552] [PI] No more function calls - research complete
[2025-10-01T16:04:13.960865] Saving text to bench_final/run1/medmcqa/medmcqa_1719/pi_final_answer.txt
[2025-10-01T16:04:13.964228] [QUERYOME] Query completed successfully
