[2025-10-01T15:33:16.639480] [QUERYOME] Starting research for query 105: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
Which of the following drug must be sold only on production of a prescription by a registered medical practitioner?

Options:
A. Schedule H
B. Schedule G
C. Schedule X
D. Schedule M'
[2025-10-01T15:33:16.690223] [PI] Starting research for query: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
Which of the following drug must be sold only on production of a prescription by a registered medical practitioner?

Options:
A. Schedule H
B. Schedule G
C. Schedule X
D. Schedule M'
[2025-10-01T15:33:16.692789] Saving text to bench_final/run1/medmcqa/medmcqa_1665/pi_initial_prompt.txt
[2025-10-01T15:33:16.697638] [PI] Calling o3 for initial analysis...
[2025-10-01T15:33:29.511839] [PI] Reasoning iteration 1
[2025-10-01T15:33:29.513453] [PI reasoning] **Exploring prescription drug regulations**

I need to find out which drugs can only be sold with a prescription from a registered medical practitioner. In India, Schedule H includes prescription drugs available at retail only with a prescription, while Schedule X involves narcotic and psychotropic substances that have even stricter regulations, including additional record-keeping and a two-year retention of prescriptions. Both schedules require prescriptions, answering the question about restricted drug sales.
[2025-10-01T15:33:29.516060] [PI] Executing function call 1: bm25_mesh_terms_search
[2025-10-01T15:33:29.517896] [PI] Function arguments: {'query': 'Schedule H drugs sold by retail only on prescription registered medical practitioner', 'k': 5}
[2025-10-01T15:33:29.519873] Saving JSON to bench_final/run1/medmcqa/medmcqa_1665/pi_iteration_1_tool_call_2_bm25_mesh_terms_search.json
[2025-10-01T15:33:30.407989] [PI] Function bm25_mesh_terms_search executed successfully
[2025-10-01T15:33:30.411222] Saving JSON to bench_final/run1/medmcqa/medmcqa_1665/pi_iteration_1_tool_result_2_bm25_mesh_terms_search.json
[2025-10-01T15:33:30.417545] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T15:33:34.259322] [PI] Reasoning iteration 2
[2025-10-01T15:33:34.261814] [PI] Executing function call 1: hybrid_search
[2025-10-01T15:33:34.263590] [PI] Function arguments: {'query': 'Schedule H drugs retail prescription registered medical practitioner India Drugs and Cosmetics Rules', 'k': 10, 'faiss_weight': 0.3, 'bm25_weight': 0.7, 'use_rrf': True}
[2025-10-01T15:33:34.266546] Saving JSON to bench_final/run1/medmcqa/medmcqa_1665/pi_iteration_2_tool_call_2_hybrid_search.json
[2025-10-01T15:33:38.074472] [PI] Function hybrid_search executed successfully
[2025-10-01T15:33:38.076826] Saving JSON to bench_final/run1/medmcqa/medmcqa_1665/pi_iteration_2_tool_result_2_hybrid_search.json
[2025-10-01T15:33:38.082108] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T15:33:46.313420] [PI] Reasoning iteration 3
[2025-10-01T15:33:46.314924] [PI reasoning] **Examining Schedule H regulations**

I’ve found some evidence relating to Schedule H, which indicates that prescription-only drugs constituted a significant portion—55.09%—of dispensed medications, according to an article I retrieved. I'll reference this article by Nagaraj et al. (2015) with PMID 26266135, highlighting the necessity of a prescription for Schedule H drugs. Additionally, I want to include another citation related to drug labeling compliance to reinforce this point. Let’s dive into crafting the answer with this information!
[2025-10-01T15:33:46.317120] [PI] No function calls found in response
[2025-10-01T15:33:46.319679] [PI] No more function calls - research complete
[2025-10-01T15:33:46.322277] Saving text to bench_final/run1/medmcqa/medmcqa_1665/pi_final_answer.txt
[2025-10-01T15:33:46.327805] [QUERYOME] Query completed successfully
