[2025-10-01T14:59:35.552750] [QUERYOME] Starting research for query 36: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
Etanercept is a disease-modifying drug used in management of rheumatoid ahritis. What is its mechanism of action?

Options:
A. Inhibition of TNF alpha
B. COX-2 inhibition
C. IL-6 inhibition
D. Stabilization of mast cells'
[2025-10-01T14:59:35.616828] [PI] Starting research for query: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
Etanercept is a disease-modifying drug used in management of rheumatoid ahritis. What is its mechanism of action?

Options:
A. Inhibition of TNF alpha
B. COX-2 inhibition
C. IL-6 inhibition
D. Stabilization of mast cells'
[2025-10-01T14:59:35.618595] Saving text to bench_final/run1/medmcqa/medmcqa_1596/pi_initial_prompt.txt
[2025-10-01T14:59:35.643068] [PI] Calling o3 for initial analysis...
[2025-10-01T14:59:39.214166] [PI] Reasoning iteration 1
[2025-10-01T14:59:39.216915] [PI] Executing function call 1: hybrid_search
[2025-10-01T14:59:39.222365] [PI] Function arguments: {'query': 'etanercept mechanism of action soluble TNF receptor fusion protein inhibits tumor necrosis factor rheumatoid arthritis', 'k': 5, 'faiss_weight': 0.7, 'bm25_weight': 0.3, 'use_rrf': True}
[2025-10-01T14:59:39.226909] Saving JSON to bench_final/run1/medmcqa/medmcqa_1596/pi_iteration_1_tool_call_3_hybrid_search.json
[2025-10-01T14:59:42.015013] [PI] Function hybrid_search executed successfully
[2025-10-01T14:59:42.020744] Saving JSON to bench_final/run1/medmcqa/medmcqa_1596/pi_iteration_1_tool_result_3_hybrid_search.json
[2025-10-01T14:59:42.031543] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T14:59:46.614621] [PI] Reasoning iteration 2
[2025-10-01T14:59:46.617521] [PI] No function calls found in response
[2025-10-01T14:59:46.619515] [PI] No more function calls - research complete
[2025-10-01T14:59:46.622358] Saving text to bench_final/run1/medmcqa/medmcqa_1596/pi_final_answer.txt
[2025-10-01T14:59:46.645060] [QUERYOME] Query completed successfully
