[2025-10-01T14:58:07.170211] [QUERYOME] Starting research for query 31: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
Which of the following types of lipase is controlled by glucagon?

Options:
A. Lipoprotein lipase
B. Hormone-sensitive lipase
C. Gastric lipase
D. Pancreatic lipase'
[2025-10-01T14:58:07.214974] [PI] Starting research for query: 'Instructions:
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer.

Question:
Which of the following types of lipase is controlled by glucagon?

Options:
A. Lipoprotein lipase
B. Hormone-sensitive lipase
C. Gastric lipase
D. Pancreatic lipase'
[2025-10-01T14:58:07.218634] Saving text to bench_final/run1/medmcqa/medmcqa_1591/pi_initial_prompt.txt
[2025-10-01T14:58:07.224454] [PI] Calling o3 for initial analysis...
[2025-10-01T14:58:14.965473] [PI] Reasoning iteration 1
[2025-10-01T14:58:14.967344] [PI reasoning] **Evaluating lipase regulation**

I need to answer a multiple-choice question about which lipase is controlled by glucagon. The answer is hormone-sensitive lipase (HSL), as glucagon activates it in adipocytes through cAMP, which promotes lipolysis. I'm considering citations from studies like Holm (2000) or Kersten (2014) for support. It seems best to search for relevant studies to ensure I have the correct references. Let’s get started on that search to find more precise information.
[2025-10-01T14:58:14.969119] [PI] Executing function call 1: hybrid_search
[2025-10-01T14:58:14.972056] [PI] Function arguments: {'query': 'glucagon activates hormone sensitive lipase lipolysis cAMP adipocytes', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T14:58:14.973947] Saving JSON to bench_final/run1/medmcqa/medmcqa_1591/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-10-01T14:58:16.745184] [PI] Function hybrid_search executed successfully
[2025-10-01T14:58:16.749241] Saving JSON to bench_final/run1/medmcqa/medmcqa_1591/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-10-01T14:58:16.758015] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T14:58:24.943580] [PI] Reasoning iteration 2
[2025-10-01T14:58:24.948058] [PI] No function calls found in response
[2025-10-01T14:58:24.950002] [PI] No more function calls - research complete
[2025-10-01T14:58:24.953011] Saving text to bench_final/run1/medmcqa/medmcqa_1591/pi_final_answer.txt
[2025-10-01T14:58:24.957708] [QUERYOME] Query completed successfully
