[2025-10-01T13:31:09.149902] [QUERYOME] Starting research for query 1532: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Mantle cell Carcinoma shows 

Options:
{'A': 'CD 5+, CD 25-', 'B': 'CD 5+, CD 10+', 'C': 'CD 5+, CD 23+', 'D': 'CD 5+, CD 23-'}'
[2025-10-01T13:31:09.230528] [PI] Starting research for query: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Mantle cell Carcinoma shows 

Options:
{'A': 'CD 5+, CD 25-', 'B': 'CD 5+, CD 10+', 'C': 'CD 5+, CD 23+', 'D': 'CD 5+, CD 23-'}'
[2025-10-01T13:31:09.231926] Saving text to bench_final/run1/medmcqa/medmcqa_1531/pi_initial_prompt.txt
[2025-10-01T13:31:09.262708] [PI] Calling o3 for initial analysis...
[2025-10-01T13:31:17.665245] [PI] Reasoning iteration 1
[2025-10-01T13:31:17.666980] [PI reasoning] **Clarifying Mantle Cell Lymphoma Markers**

I need to focus on the immunophenotype of Mantle cell lymphoma, not carcinoma, since they mistakenly wrote carcinoma. Mantle cell lymphoma is generally CD5 positive and CD23 negative, while also being CD10 negative. So the correct answer should be CD5+, CD23- (Option D). Essentially, this lymphoma shows pan B-cell antigens, including CD5, but lacks CD23 and CD10. I'll gather literature references to support this information, like those from Herrmann 2018 and Swerdlow’s classification.
[2025-10-01T13:31:17.670028] [PI] Executing function call 1: hybrid_search
[2025-10-01T13:31:17.671864] [PI] Function arguments: {'query': 'mantle cell lymphoma immunophenotype CD5 positive CD23 negative', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T13:31:17.674366] Saving JSON to bench_final/run1/medmcqa/medmcqa_1531/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-10-01T13:32:06.809772] [PI] Function hybrid_search executed successfully
[2025-10-01T13:32:06.816744] Saving JSON to bench_final/run1/medmcqa/medmcqa_1531/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-10-01T13:32:06.826709] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T13:32:11.316648] [PI] Reasoning iteration 2
[2025-10-01T13:32:11.319425] [PI] No function calls found in response
[2025-10-01T13:32:11.321314] [PI] No more function calls - research complete
[2025-10-01T13:32:11.324391] Saving text to bench_final/run1/medmcqa/medmcqa_1531/pi_final_answer.txt
[2025-10-01T13:32:11.329792] [QUERYOME] Query completed successfully
