[2025-10-01T11:20:29.652588] [QUERYOME] Starting research for query 1458: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Which of the following drug is contraindicated in pregnancy? 

Options:
{'A': 'Enalapril', 'B': 'Amlodipine', 'C': 'b-blockers', 'D': 'Propylthiouracil'}'
[2025-10-01T11:20:29.716638] [PI] Starting research for query: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
Which of the following drug is contraindicated in pregnancy? 

Options:
{'A': 'Enalapril', 'B': 'Amlodipine', 'C': 'b-blockers', 'D': 'Propylthiouracil'}'
[2025-10-01T11:20:29.719455] Saving text to bench_final/run1/medmcqa/medmcqa_1457/pi_initial_prompt.txt
[2025-10-01T11:20:29.745705] [PI] Calling o3 for initial analysis...
[2025-10-01T11:20:46.664020] [PI] Reasoning iteration 1
[2025-10-01T11:20:46.669783] [PI reasoning] **Identifying Contraindicated Drug in Pregnancy**

I need to determine which drug among Enalapril, Amlodipine, beta-blockers, and Propylthiouracil (PTU) is contraindicated in pregnancy. Enalapril, an ACE inhibitor, is contraindicated due to risks like renal dysgenesis and oligohydramnios. Amlodipine is typically categorized as C, meaning it's not strictly contraindicated. While some beta-blockers can be safe, PTU is safe in the first trimester for hyperthyroidism. Thus, the answer is Enalapril, and I’ll gather evidence to support this.
[2025-10-01T11:20:46.671503] [PI] Executing function call 1: hybrid_search
[2025-10-01T11:20:46.674339] [PI] Function arguments: {'query': 'enalapril contraindicated pregnancy ace inhibitor teratogenic oligohydramnios renal dysgenesis fetal anomalies', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T11:20:46.676004] Saving JSON to bench_final/run1/medmcqa/medmcqa_1457/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-10-01T11:21:16.544424] [PI] Function hybrid_search executed successfully
[2025-10-01T11:21:16.546268] Saving JSON to bench_final/run1/medmcqa/medmcqa_1457/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-10-01T11:21:16.552380] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T11:21:20.266082] [PI] Reasoning iteration 2
[2025-10-01T11:21:20.268755] [PI] Executing function call 1: hybrid_search
[2025-10-01T11:21:20.270210] [PI] Function arguments: {'query': 'amlodipine use in pregnancy safety data', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T11:21:20.271350] Saving JSON to bench_final/run1/medmcqa/medmcqa_1457/pi_iteration_2_tool_call_2_hybrid_search.json
[2025-10-01T11:21:37.508976] [PI] Function hybrid_search executed successfully
[2025-10-01T11:21:37.510698] Saving JSON to bench_final/run1/medmcqa/medmcqa_1457/pi_iteration_2_tool_result_2_hybrid_search.json
[2025-10-01T11:21:37.529374] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T11:21:48.075353] [PI] Reasoning iteration 3
[2025-10-01T11:21:48.077349] [PI] No function calls found in response
[2025-10-01T11:21:48.080713] [PI] No more function calls - research complete
[2025-10-01T11:21:48.082968] Saving text to bench_final/run1/medmcqa/medmcqa_1457/pi_final_answer.txt
[2025-10-01T11:21:48.089935] [QUERYOME] Query completed successfully
