[2025-10-01T07:43:21.534777] [QUERYOME] Starting research for query 1306: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
All of the following are seen in MEN-1 syndrome except: 

Options:
{'A': 'Posterior pituitary tumors', 'B': 'Pancreatic neuroendocrine tumors', 'C': 'Foregut carcinoid', 'D': 'Parathyroid hyperplasia'}'
[2025-10-01T07:43:21.586622] [PI] Starting research for query: 'Instructions: 
 Answer the question below. First, respond with the single best option letter (A, B, C, or D). Then provide a concise reasoning (1–3 sentences). Use both the retrieved evidence and your own medical knowledge to choose the most accurate answer. 

Question:
All of the following are seen in MEN-1 syndrome except: 

Options:
{'A': 'Posterior pituitary tumors', 'B': 'Pancreatic neuroendocrine tumors', 'C': 'Foregut carcinoid', 'D': 'Parathyroid hyperplasia'}'
[2025-10-01T07:43:21.595192] Saving text to bench_final/run1/medmcqa/medmcqa_1305/pi_initial_prompt.txt
[2025-10-01T07:43:21.600216] [PI] Calling o3 for initial analysis...
[2025-10-01T07:43:29.095007] [PI] Reasoning iteration 1
[2025-10-01T07:43:29.096694] [PI reasoning] **Considering MEN-1 exclusions**

I need to answer a question regarding which tumors are not seen in MEN-1. MEN-1 includes parathyroid hyperplasia, pancreatic neuroendocrine tumors, and anterior pituitary adenomas, but not posterior pituitary tumors. Foregut carcinoids are associated with MEN-1, so the exception is likely posterior pituitary tumors. I’ll also conduct a quick search to find relevant articles for evidence and reference sources that detail MEN-1's associations with these tumors.
[2025-10-01T07:43:29.103604] [PI] Executing function call 1: hybrid_search
[2025-10-01T07:43:29.120552] [PI] Function arguments: {'query': 'multiple endocrine neoplasia type 1 posterior pituitary tumors', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T07:43:29.123319] Saving JSON to bench_final/run1/medmcqa/medmcqa_1305/pi_iteration_1_tool_call_2_hybrid_search.json
[2025-10-01T07:44:00.415370] [PI] Function hybrid_search executed successfully
[2025-10-01T07:44:00.417022] Saving JSON to bench_final/run1/medmcqa/medmcqa_1305/pi_iteration_1_tool_result_2_hybrid_search.json
[2025-10-01T07:44:00.430701] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T07:44:03.651633] [PI] Reasoning iteration 2
[2025-10-01T07:44:03.653227] [PI] Executing function call 1: hybrid_search
[2025-10-01T07:44:03.656853] [PI] Function arguments: {'query': 'foregut carcinoid tumors MEN1', 'k': 10, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T07:44:03.658380] Saving JSON to bench_final/run1/medmcqa/medmcqa_1305/pi_iteration_2_tool_call_2_hybrid_search.json
[2025-10-01T07:44:40.802544] [PI] Function hybrid_search executed successfully
[2025-10-01T07:44:40.809084] Saving JSON to bench_final/run1/medmcqa/medmcqa_1305/pi_iteration_2_tool_result_2_hybrid_search.json
[2025-10-01T07:44:40.818624] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T07:44:44.932027] [PI] Reasoning iteration 3
[2025-10-01T07:44:44.934862] [PI] Executing function call 1: hybrid_search
[2025-10-01T07:44:44.936678] [PI] Function arguments: {'query': 'parathyroid hyperplasia multiple endocrine neoplasia type 1', 'k': 5, 'faiss_weight': 0.6, 'bm25_weight': 0.4, 'use_rrf': True}
[2025-10-01T07:44:44.938107] Saving JSON to bench_final/run1/medmcqa/medmcqa_1305/pi_iteration_3_tool_call_2_hybrid_search.json
[2025-10-01T07:44:59.563398] [PI] Function hybrid_search executed successfully
[2025-10-01T07:44:59.568623] Saving JSON to bench_final/run1/medmcqa/medmcqa_1305/pi_iteration_3_tool_result_2_hybrid_search.json
[2025-10-01T07:44:59.580087] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T07:45:03.546032] [PI] Reasoning iteration 4
[2025-10-01T07:45:03.548019] [PI] Executing function call 1: hybrid_search
[2025-10-01T07:45:03.551068] [PI] Function arguments: {'query': 'posterior pituitary tumor pituicytoma MEN1', 'k': 10, 'faiss_weight': 0.7, 'bm25_weight': 0.3, 'use_rrf': True}
[2025-10-01T07:45:03.553349] Saving JSON to bench_final/run1/medmcqa/medmcqa_1305/pi_iteration_4_tool_call_2_hybrid_search.json
[2025-10-01T07:45:38.867894] [PI] Function hybrid_search executed successfully
[2025-10-01T07:45:38.871207] Saving JSON to bench_final/run1/medmcqa/medmcqa_1305/pi_iteration_4_tool_result_2_hybrid_search.json
[2025-10-01T07:45:38.886269] [PI] Continuing reasoning with 1 function responses...
[2025-10-01T07:45:47.743070] [PI] Reasoning iteration 5
[2025-10-01T07:45:47.745403] [PI] No function calls found in response
[2025-10-01T07:45:47.748622] [PI] No more function calls - research complete
[2025-10-01T07:45:47.751062] Saving text to bench_final/run1/medmcqa/medmcqa_1305/pi_final_answer.txt
[2025-10-01T07:45:47.760288] [QUERYOME] Query completed successfully
