D

pRb, FHIT, and PTCH all function as classic tumor-suppressor genes, whereas c-erbB1 (the epidermal growth factor receptor/EGFR) is a proto-oncogene that promotes cell proliferation when over-expressed or mutated, not a suppressor [Goodrich, 2006, PMID 16936742; Boutet, 2003, PMID 12925203; Beckmann, 1993, PMID 7904970].