C

Primaquine is the only widely-used antimalarial that reliably destroys mature gametocytes of every human Plasmodium species, including P. falciparum as well as the non-falciparum species; neither chloroquine nor quinine is effective against all species’ gametocytes [White, 2013, PMID 23182932; Recht, 2018, PMID 29672516].