A

Bisphosphonates bind to bone mineral and are taken up by active osteoclasts, where they block steps in the mevalonate pathway or form toxic ATP analogues, leading to loss of osteoclast function and apoptosis; their principal effect is therefore inhibition of osteoclast-mediated bone resorption, not stimulation of osteoid formation or mineralization [Rogers, 2003, PMID 14529538].