A

Impulse propagation in myelinated axons is much faster—not slower—than in unmyelinated axons because the action potential “jumps” from one node of Ranvier to the next (saltatory conduction) [Kier et al., 2015, PMID 26205832]. Membrane currents are generated at these nodes, and local anesthetics act there, blocking conduction when several successive nodes are affected, even though the intervening internodes remain myelinated [Raymond et al., 1989, PMID 2785778].