PPI-Surfer is a protein-protein interface comparison program that uses local surface matching between the PPIs. It uses three-dimensional Zernike descriptor to calculate similarity of the patches. Detailed description of the program is given in the reference below:

  • W.-H. Shin, K. Kumazawa, K. Imai, H. Takatsugu, and D. Kihara*, Quantitative Comparison of Protein-Protein Interaction Interface Using Physico-Chemical Feature-Based Descriptors of Surface Patches, Front. Mol. Biosci. Submitted.

    Binary executible files, running python scripts, and example can be freely downloadable at the following link.


    Contact Information

    If you have any questions or suggestions, please feel free to contact us (dkihara@purdue.edu).